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Warfarin is essentially completely absorbed after oral administrationwith peak concentration generally attained within the first 4 hours.

Necrosis and/or gangrene of skin and other tissues is an uncommon but serious risk

COUMADIN is a racemic mixture of the Rand Senantiomers of warfarinThe Senantiomer exhibits 2 to 5 times more anticoagulant activity than the R-enantiomer in humansbut generally has a more rapid clearance.

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